Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Cdx2  caudal type homeobox 2   (Synonyms: Cdx-2)
Results	Reference
1*	J:310134 Adachi K, Nikaido I, Ohta H, Ohtsuka S, Ura H, Kadota M, Wakayama T, Ueda HR, Niwa H, Context-dependent wiring of Sox2 regulatory networks for self-renewal of embryonic and trophoblast stem cells. Mol Cell. 2013 Nov 7;52(3):380-92
1	J:160922 Ahmed K, Dehghani H, Rugg-Gunn P, Fussner E, Rossant J, Bazett-Jones DP, Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo. PLoS One. 2010;5(5):e10531
1*	J:29512 Beck F, Erler T, Russell A, James R, Expression of Cdx-2 in the mouse embryo and placenta: possible role in patterning of the extra-embryonic membranes. Dev Dyn. 1995 Nov;204(3):219-27
1	J:183847 Bedzhov I, Liszewska E, Kanzler B, Stemmler MP, Igf1r signaling is indispensable for preimplantation development and is activated via a novel function of E-cadherin. PLoS Genet. 2012 Mar;8(3):e1002609
1	J:199463 Cockburn K, Biechele S, Garner J, Rossant J, The hippo pathway member nf2 is required for inner cell mass specification. Curr Biol. 2013 Jul 8;23(13):1195-201
1	J:320718 Duethorn B, Groll F, Rieger B, Drexler HCA, Brinkmann H, Kremer L, Stehling M, Borowski MT, Mildner K, Zeuschner D, Zernicka-Goetz M, Stemmler MP, Busch KB, Vaquerizas JM, Bedzhov I, Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism. Nat Commun. 2022 Feb 1;13(1):610
1*	J:193806 Garcia-Tunon I, Guallar D, Alonso-Martin S, Benito AA, Benitez-Lazaro A, Perez-Palacios R, Muniesa P, Climent M, Sanchez M, Vidal M, Schoorlemmer J, Association of Rex-1 to target genes supports its interaction with Polycomb function. Stem Cell Res. 2011 Jul;7(1):1-16
1*	J:110696 Gonzalez MA, Tachibana KE, Adams DJ, van der Weyden L, Hemberger M, Coleman N, Bradley A, Laskey RA, Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development. Genes Dev. 2006 Jul 15;20(14):1880-4
1	J:143453 Jedrusik A, Parfitt DE, Guo G, Skamagki M, Grabarek JB, Johnson MH, Robson P, Zernicka-Goetz M, Role of Cdx2 and cell polarity in cell allocation and specification of trophectoderm and inner cell mass in the mouse embryo. Genes Dev. 2008 Oct 1;22(19):2692-706
1*	J:189008 Jia Y, Viswakarma N, Crawford SE, Sarkar J, Sambasiva Rao M, Karpus WJ, Kanwar YS, Zhu YJ, Reddy JK, Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene. Mech Dev. 2012 Sep;129(9-12):193-207
1	J:321498 Kim EJY, Sorokin L, Hiiragi T, ECM-integrin signalling instructs cellular position sensing to pattern the early mouse embryo. Development. 2022 Jan 1;149(1):dev200140
1*	J:163559 Messerschmidt DM, Kemler R, Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism. Dev Biol. 2010 Aug 1;344(1):129-37
1	J:312811 Modzelewski AJ, Shao W, Chen J, Lee A, Qi X, Noon M, Tjokro K, Sales G, Biton A, Anand A, Speed TP, Xuan Z, Wang T, Risso D, He L, A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development. Cell. 2021 Oct 28;184(22):5541-5558.e22
1*	J:265825 Molotkov A, Soriano P, Distinct mechanisms for PDGF and FGF signaling in primitive endoderm development. Dev Biol. 2018 Oct 1;442(1):155-161
1	J:224146 O'Shaughnessy-Kirwan A, Signolet J, Costello I, Gharbi S, Hendrich B, Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification. Development. 2015 Aug 1;142(15):2586-97
1*	J:227373 Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H, The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell. 2012 Sep 7;11(3):319-32
1*	J:156174 Ralston A, Cox BJ, Nishioka N, Sasaki H, Chea E, Rugg-Gunn P, Guo G, Robson P, Draper JS, Rossant J, Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2. Development. 2010 Feb;137(3):395-403
1*	J:130330 Ralston A, Rossant J, Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo. Dev Biol. 2008 Jan 15;313(2):614-29
1*	J:118119 Sakaki-Yumoto M, Kobayashi C, Sato A, Fujimura S, Matsumoto Y, Takasato M, Kodama T, Aburatani H, Asashima M, Yoshida N, Nishinakamura R, The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Development. 2006 Aug;133(15):3005-13
1	J:326954 Seong J, Frias-Aldeguer J, Holzmann V, Kagawa H, Sestini G, Heidari Khoei H, Scholte Op Reimer Y, Kip M, Pradhan SJ, Verwegen L, Vivie J, Li L, Alemany A, Korving J, Darmis F, van Oudenaarden A, Ten Berge D, Geijsen N, Rivron NC, Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero. Cell Stem Cell. 2022 Jul 7;29(7):1102-1118.e8
1*	J:275903 Shiura H, Abe K, Xist/Tsix expression dynamics during mouse peri-implantation development revealed by whole-mount 3D RNA-FISH. Sci Rep. 2019 Mar 6;9(1):3637
1	J:165812 Stephenson RO, Yamanaka Y, Rossant J, Disorganized epithelial polarity and excess trophectoderm cell fate in preimplantation embryos lacking E-cadherin. Development. 2010 Oct;137(20):3383-91
1*	J:98502 Strumpf D, Mao CA, Yamanaka Y, Ralston A, Chawengsaksophak K, Beck F, Rossant J, Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development. 2005 May;132(9):2093-102
1*	J:172504 Szczepanska K, Stanczuk L, Maleszewski M, Isolated mouse inner cell mass is unable to reconstruct trophectoderm. Differentiation. 2011 Jul;82(1):1-8
1	J:266780 Watanabe Y, Miyasaka KY, Kubo A, Kida YS, Nakagawa O, Hirate Y, Sasaki H, Ogura T, Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm. Sci Rep. 2017 Apr 12;7:46135
1	J:316544 Zheng X, Yang P, Lackford B, Bennett BD, Wang L, Li H, Wang Y, Miao Y, Foley JF, Fargo DC, Jin Y, Williams CJ, Jothi R, Hu G, CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State. Stem Cell Reports. 2016 Nov 8;7(5):897-910